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Dramatically Different Moisturising Lotion+™ 50ml

Product code: T239234F

Dermatologist-developed silky, fast-absorbing moisturising lotion with pure urea rapidly strengthens the skin barrier. Dermatologist developed. Dermatologist tested. Non-comedogenic. Suitable for post-procedure skin. Allergy tested. 100% fragrance free.

Our daily urea moisturiser for face delivers hydration + soothing moisture for skin in need of comfort. Hydrates to soften and smooth. Helps strengthen skin’s own moisture barrier so more moisture stays in. Replenishes skin’s oil-water balance for healthy-looking skin. Silky lotion slips on easily, absorbs quickly. Appropriate for use as soon as 1 day post treatment. *Shown to be safe for use following a non-ablative laser treatment in a two-week clinical usage test.

Clinique

Dramatically Different Moisturising Lotion+™ 50ml

€30

€6 per 10ml

Also available in: Moisturising Gel and Moisturising Lotion
Free standard delivery over €75

Reviews (19)

4.8

63% Recommended this product

Mentions
22 March 2026Blue Fan Lady

A classic favourite

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

My sister has been wearing this product since it first became available in the UK. I always try to gift her a bottle for her birthday as I know she enjoys how her skin feels when she wears it

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

22 November 2025Writer34

A good quality moisturiser

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

This was a repeat purchase. A good moisturiser that suits delicate skin. Surprised to find it's only available online now.

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

17 November 2025Flowersandshoes

Xmass

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

Again got my husband to buy for my Christmas as I always use this

Helpful?

04 October 2025Suz0

Great product

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

I have used Clinique for many years. It’s a good moisturiser.

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

30 September 2025Barbi20

Soft and smooth

Originally posted on marksandspencer.com (UK)

Good moisturiser that sinks into the skin giving a good base for foundation.

Helpful?

25 September 2024jianjie

Usual consistent quality

Originally posted on marksandspencer.com (UK)

Usual quality from Clinique. Convenient size of package been using it to good effect for years.

Helpful?

23 September 2024hotmagenta

Non greasy

Originally posted on marksandspencer.com (UK)

Nice cream in a tube good for travelling. It moisturizes without feeling greasy.

Helpful?

10 August 2024Brdigit

Got in gift set but would not spend money

Originally posted on marksandspencer.com (UK)

No, I don't recommend this

I got this product as part of the gift set and I think it's overpriced for cheap ingredients. My skin did not like this formula and became red and sensitive. Step it up Clinique, the direction now in skin care cosmetics are peptides and ferments. I'd also love to see less HA in products as it does nothing for the skin, except it sits on the surface, as even when emulsified it's molecular size si too big to penetrate in between cells. HA only makes the skin look good for about an hour then the skin looks dry and inflamed.

Reviewer Ratings

Quality

Poor

Value for Money

Poor

Helpful?

Reviewer Ratings

Quality

Poor

Value for Money

Poor

08 March 2024Doodle21

Must have

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

Fantastic must have. Unscented which is great for sensitive skin. Worth the money

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

14 February 2024Why so hard to review

Dramatically different moisturiser lotion

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

Love this, tried other brands but always come back to this.

Reviewer Ratings

Quality

Excellent

Value for Money

Good

Helpful?

Reviewer Ratings

Quality

Excellent

Value for Money

Good

29 December 2022DMgarden1

My favourite moisturiser

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

This never fails to deliver a lovely skin quenching feel

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

15 December 2022Elizabeth Evans

Clinique face cream

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

Does what it says on the tin suits my skin used it years ago and recently started using again

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

25 September 2022Billie Mills

Moisture essential

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

I’ve used this for years, and it has helped to keep my wrinkles to the minimum.

Helpful?

14 September 2022Carolbriar

Great size for travel

Originally posted on marksandspencer.com (UK)

A light moisturiser which I have been using for some time. This is a handy size for travelling which is why I bought it.

Reviewer Ratings

Value for Money

Good

Helpful?

Reviewer Ratings

Value for Money

Good

04 September 2022tss mitch

Moisturiser by Clinique

Originally posted on marksandspencer.com (UK)

I have used this item for years. It is a very good moisturiser which leaves skin feeling soft and dewy.

Helpful?

09 June 2022Seaside 95

Cool looking skin

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

I have always used this. It makes your skin feels good

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

03 June 2022Trendytuniclady

A reliable product

Originally posted on marksandspencer.com (UK)

A firm favourite - suits many skin types. Value for money

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

31 May 2022Scottish Shopaholic

Nice Product

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

Makes my skin feel more hydrated and less "tight".

Reviewer Ratings

Quality

Excellent

Value for Money

Good

Helpful?

Reviewer Ratings

Quality

Excellent

Value for Money

Good

16 May 2022KT23

The only moisturiser I use

Originally posted on marksandspencer.com (UK)

Yes, I recommend this

I have used Clinique Dramatically Different Moisturising Lotion for over 20 years and would definitely recommend to anyone with sensitive skin. Very happy M and S have started to stock Clinique.

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

Value for Money

Excellent

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